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Mistral Medium 3.5 128B VRAM Requirements

Mistral AI, France · Released May 22, 2026

Mistral Medium 3.5 128B has 127.7B parameters. In BF16 its weights alone take 238 GiB; quantized to 4-bit, about 70.6 GiB. Each 32K-token request adds 11.0 GiB of KV cache. Cheapest way to run it today: 6 × RTX A4000 (16 GB) at $0.432 per hour. It reads text and images, calls tools and lets you set its reasoning effort.

Size your own setup in the calculator →

Mistral Medium 3.5 128B at a glance

Made by
Mistral AI, France
Released
May 22, 2026
Parameters
127.7B
Context window
256K tokens
License
Custom license
Reads
Text and images
Tool calling
Supported
Reasoning
Adjustable reasoning effort
Languages
English, French, German, Spanish, Portuguese, Italian and 18 more
Runs with
vLLM, SGLang, llama.cpp (Ollama, LM Studio), MLX (Mac) · vLLM recipe (opens in a new tab)
Checked against

KV cache matches the GGUF header of unsloth/Mistral-Medium-3.5-128B-GGUF (opens in a new tab) (what llama.cpp allocates), October 30, 2026

On Ollama
ollama run mistral-medium-3.5:128b · Q4_K_M, 74.7 GiB 436K pulls (opens in a new tab)

VRAM by precision and context length

Weights plus the KV cache of one request (BF16 cache), in GiB. Add 1 to 3 GiB for the inference engine itself.

Weights formatWeights only+ 8K context+ 32K context+ 128K context+ 256K context
FP8 (native)124127135168212
BF16 / FP16238241249282326
FP8 / INT8122125133166210
4-bit (GGUF Q4_K_M)70.673.481.6115159

Mistral Medium 3.5 128B GGUF files

Exact size of each quantization in unsloth/Mistral-Medium-3.5-128B-GGUF (opens in a new tab), and the smallest GPU that runs it with llama.cpp, Ollama or LM Studio and an 8K-token context.

QuantizationFile sizeSmallest GPU
BF16233 GiBMore than 96 GB: see the calculator
Q8_0124 GiBMore than 96 GB: see the calculator
Q6_K95.5 GiBMore than 96 GB: see the calculator
Q5_K_M82.3 GiBRTX PRO 6000 Blackwell (96 GB)
Q4_K_M69.8 GiBRTX PRO 6000 Blackwell (96 GB)
IQ4_XS62.5 GiBRTX PRO 6000 Blackwell (96 GB)
Q3_K_M56.5 GiBRTX PRO 6000 Blackwell (96 GB)
Q2_K43.4 GiBRTX 6000 Ada (48 GB)
UD-IQ2_XXS32.5 GiBRTX 6000 Ada (48 GB)
Show the other 15 files
QuantizationFile sizeSmallest GPU
UD-Q8_K_XL135 GiBMore than 96 GB: see the calculator
UD-Q6_K_XL102 GiBMore than 96 GB: see the calculator
UD-Q5_K_XL82.3 GiBRTX PRO 6000 Blackwell (96 GB)
Q5_K_S80.3 GiBRTX PRO 6000 Blackwell (96 GB)
Q4_173.1 GiBRTX PRO 6000 Blackwell (96 GB)
UD-Q4_K_XL70.5 GiBRTX PRO 6000 Blackwell (96 GB)
Q4_K_S66.4 GiBRTX PRO 6000 Blackwell (96 GB)
Q4_066.1 GiBRTX PRO 6000 Blackwell (96 GB)
IQ4_NL66.0 GiBRTX PRO 6000 Blackwell (96 GB)
UD-Q3_K_XL58.2 GiBRTX PRO 6000 Blackwell (96 GB)
Q3_K_S50.6 GiBRTX PRO 6000 Blackwell (96 GB)
UD-IQ3_XXS45.9 GiBRTX PRO 6000 Blackwell (96 GB)
UD-Q2_K_XL44.8 GiBRTX PRO 6000 Blackwell (96 GB)
Q2_K_L43.7 GiBRTX 6000 Ada (48 GB)
UD-IQ2_M41.1 GiBRTX 6000 Ada (48 GB)

Read every day from Hugging Face. Split files are added together; vision projectors are left out.

How many GPUs to run Mistral Medium 3.5 128B

Fewest GPUs that fit the weights plus one 8K-token request. Data-center GPUs use vLLM (90% of memory usable), the others llama.cpp. Several GPUs split the model with tensor or pipeline parallelism.

GPUFP8 (native)BF16 / FP168-bit4-bit
GeForce RTX 4090 24 GBNot on this GPU16 (several machines)74
GeForce RTX 5090 32 GBNot on this GPU16 (several machines)53
RTX PRO 6000 Blackwell 96 GBNot on this GPU321
Mac M5 Max 128 GB 96 GB usableNot on this GPU321
Ryzen AI Max+ 395 128 GB 96 GB usableNot on this GPU321
DGX Spark (GB10) 128 GBNot on this GPU211
NVIDIA H100 80 GB2422
NVIDIA H200 141 GB2221
NVIDIA B200 (HGX) 180 GB1211

8-bit: FP8 with vLLM (INT8 on GPUs without FP8), Q8_0 with llama.cpp. 4-bit: AWQ / GPTQ with vLLM, Q4_K_M with llama.cpp, both counted at the Q4_K_M size. Not on this GPU: the official FP8 weights do not run there (llama.cpp needs a GGUF version, and vLLM needs a GPU with FP8 support).

Cheapest way to run Mistral Medium 3.5 128B today

For each GPU: the fewest cards that fit Mistral Medium 3.5 128B with one 8K-token request, the most faithful weight format at that count, and the cheapest on-demand price (2026-10-30).

On-demand prices from AWS, Google Cloud, Azure, RunPod, Vast.ai, Oracle Cloud, OVHcloud, Scaleway, Verda, Akash and UpCloud, checked every hour. Serving many users needs more KV cache, so more memory: size it in the calculator. Some links are affiliate links: StudioTV may earn a commission, at no extra cost to you.

AWS, Google Cloud and UpCloud prices: Spare Cores (opens in a new tab), CC BY-SA 4.0 (opens in a new tab), shared under the same license.

Recommended settings for Mistral Medium 3.5 128B

Reasoning. Adjustable reasoning effort. Reasoning tokens take context and KV cache like any other token: leave room for them.

KV cache: how memory grows with context

Architecture: 88 layers · GQA, 8 KV heads × 128 · vision encoder. Every layer keeps keys and values for every token (grouped-query attention), so the cache grows linearly with context.

Context per requestBF16 cacheFP8 cache
8K tokens2.75 GiB1.38 GiB
32K tokens11.0 GiB5.50 GiB
128K tokens44.0 GiB22.0 GiB
256K tokens88.0 GiB44.0 GiB

Mistral Medium 3.5 128B VRAM FAQ

How much VRAM does Mistral Medium 3.5 128B need?

In BF16 the weights alone take 238 GiB (255 GB). In FP8 that is 122 GiB, and about 70.6 GiB with 4-bit quantization (Q4_K_M); the official FP8 checkpoint is 124 GiB. Each request then adds KV cache: 2.75 GiB at 8K tokens and 11.0 GiB at 32K (BF16 cache).

Can Mistral Medium 3.5 128B run on a single RTX 4090 (24 GB)?

No. Even in 4-bit it needs 4 RTX 4090s. In 4-bit it fits on a single RTX PRO 6000 Blackwell (96 GB).

Can Mistral Medium 3.5 128B run on an RTX 5090 (32 GB)?

No. Even in 4-bit it needs 3 RTX 5090s.

Can Mistral Medium 3.5 128B run on a Mac?

Yes. In 4-bit (Q4_K_M with llama.cpp) it needs a Mac with 128 GB of unified memory or more, of which macOS gives the GPU about 96 GB, for one request with an 8K-token context. In 8-bit (Q8_0) it needs 192 GB or more.

Can Mistral Medium 3.5 128B run on a DGX Spark or a Ryzen AI Max+ 395 (128 GB)?

Yes. On a DGX Spark (128 GB) it fits in Q8_0 (125 GiB with an 8K-token context); on a Ryzen AI Max+ 395 with 128 GB, whose GPU gets up to 96 GB, it fits in Q4_K_M (73.4 GiB with an 8K-token context), with llama.cpp and one request.

What is the cheapest way to run Mistral Medium 3.5 128B?

On 2026-10-30, the cheapest on-demand setup is 6 × RTX A4000 (16 GB) with Q4_K_M weights on Vast.ai, at $0.432 per hour (about $315.36 per month). Next: 4 × GeForce RTX 3090 (24 GB) with Q4_K_M weights on Vast.ai, at $0.484 per hour. Sized for one 8K-token request; prices are checked every hour.

How many H100 GPUs does Mistral Medium 3.5 128B need?

With one request and an 8K-token context: 4 in BF16, 2 in FP8 and 2 in 4-bit (vLLM, 90% of memory usable). Serving many users at once needs more memory for their KV caches: the calculator sizes that for you.

Can Mistral Medium 3.5 128B read images?

Yes. Mistral Medium 3.5 128B reads text and images. Images add tokens to the context, so they also add KV cache.

Does Mistral Medium 3.5 128B support tool calling?

Yes, Mistral Medium 3.5 128B supports tool (function) calling: it can ask your application to run a function and use the result.

Does Mistral Medium 3.5 128B have a thinking mode?

Adjustable reasoning effort. Reasoning tokens count toward the context and the KV cache.

Mistral Medium 3.5 128B VRAM badge

For a model card or a README: the 4-bit size and the smallest GPU it fits on, linked to this page. Data as JSON: /api/models/mistral-medium-3-5.json.

Mistral Medium 3.5 128B VRAM badge

[![Mistral Medium 3.5 128B VRAM](https://studiotvai.com/badge/mistral-medium-3-5.svg)](https://studiotvai.com/vram-requirements/mistral-medium-3-5)

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Estimates, not guarantees: computed from the official config.json with the same engine as the LLM VRAM Calculator. Real usage depends on your engine version and settings.