Mixtral 8x22B has 140.6B parameters (39B active per token). In BF16 its weights alone take 262 GiB; quantized to 4-bit, about 79.1 GiB. Each 32K-token request adds 7.00 GiB of KV cache. Cheapest way to run it today: 6 × RTX A4000 (16 GB) at $0.432 per hour. It calls tools.
Read every day from Hugging Face. Split files are added together; vision projectors are left out.
How many GPUs to run Mixtral 8x22B
Fewest GPUs that fit the weights plus one 8K-token request. Data-center GPUs use vLLM (90% of memory usable), the others llama.cpp. Several GPUs split the model with tensor or pipeline parallelism.
GPU
BF16 / FP16
8-bit
4-bit
GeForce RTX 4090 24 GB
16 (several machines)
7
4
GeForce RTX 5090 32 GB
16 (several machines)
5
3
RTX PRO 6000 Blackwell 96 GB
3
2
1
Mac M5 Max 128 GB 96 GB usable
3
2
1
Ryzen AI Max+ 395 128 GB 96 GB usable
3
2
1
DGX Spark (GB10) 128 GB
3
2
1
NVIDIA H100 80 GB
4
2
2
NVIDIA H200 141 GB
3
2
1
NVIDIA B200 (HGX) 180 GB
2
1
1
8-bit: FP8 with vLLM (INT8 on GPUs without FP8), Q8_0 with llama.cpp. 4-bit: AWQ / GPTQ with vLLM, Q4_K_M with llama.cpp, both counted at the Q4_K_M size.
Cheapest way to run Mixtral 8x22B today
For each GPU: the fewest cards that fit Mixtral 8x22B with one 8K-token request, the most faithful weight format at that count, and the cheapest on-demand price (2026-10-30).
On-demand prices from AWS, Google Cloud, Azure, RunPod, Vast.ai, Oracle Cloud, OVHcloud, Scaleway, Verda, Akash and UpCloud, checked every hour. Serving many users needs more KV cache, so more memory: size it in the calculator. Some links are affiliate links: StudioTV may earn a commission, at no extra cost to you.
The repository sets no sampling defaults: these are OpenRouter's defaults for Mixtral 8x22B.
Setting
Value
Temperature
0.3
With llama.cpp, pass them yourself: --temp 0.3
KV cache: how memory grows with context
Architecture: MoE 8 experts (2 active) · 56 layers, GQA 8 KV heads × 128. Every layer keeps keys and values for every token (grouped-query attention), so the cache grows linearly with context. Only 39B parameters are active per token, but all 141B must sit in memory: VRAM depends on the total, speed on the active part.
Context per request
BF16 cache
FP8 cache
8K tokens
1.75 GiB
0.88 GiB
32K tokens
7.00 GiB
3.50 GiB
Mixtral 8x22B VRAM FAQ
How much VRAM does Mixtral 8x22B need?
In BF16 the weights alone take 262 GiB (281 GB). In FP8 that is 131 GiB, and about 79.1 GiB with 4-bit quantization (Q4_K_M). Each request then adds KV cache: 1.75 GiB at 8K tokens and 7.00 GiB at 32K (BF16 cache).
Can Mixtral 8x22B run on a single RTX 4090 (24 GB)?
No. Even in 4-bit it needs 4 RTX 4090s. In 4-bit it fits on a single RTX PRO 6000 Blackwell (96 GB).
Can Mixtral 8x22B run on an RTX 5090 (32 GB)?
No. Even in 4-bit it needs 3 RTX 5090s.
Can Mixtral 8x22B run on a Mac?
Yes. In 4-bit (Q4_K_M with llama.cpp) it needs a Mac with 128 GB of unified memory or more, of which macOS gives the GPU about 96 GB, for one request with an 8K-token context. In 8-bit (Q8_0) it needs 192 GB or more.
Can Mixtral 8x22B run on a DGX Spark or a Ryzen AI Max+ 395 (128 GB)?
Yes. In Q4_K_M (80.9 GiB with an 8K-token context) it fits on a DGX Spark (128 GB) and on a Ryzen AI Max+ 395 with 128 GB, whose GPU gets up to 96 GB, with llama.cpp and one request.
What is the cheapest way to run Mixtral 8x22B?
On 2026-10-30, the cheapest on-demand setup is 6 × RTX A4000 (16 GB) with Q4_K_M weights on Vast.ai, at $0.432 per hour (about $315.36 per month). Next: 4 × GeForce RTX 3090 (24 GB) with Q4_K_M weights on Vast.ai, at $0.484 per hour. Sized for one 8K-token request; prices are checked every hour.
How many H100 GPUs does Mixtral 8x22B need?
With one request and an 8K-token context: 4 in BF16, 2 in FP8 and 2 in 4-bit (vLLM, 90% of memory usable). Serving many users at once needs more memory for their KV caches: the calculator sizes that for you.
Does Mixtral 8x22B support tool calling?
Yes, Mixtral 8x22B supports tool (function) calling: it can ask your application to run a function and use the result.
What temperature should I use with Mixtral 8x22B?
The repository sets no defaults; OpenRouter uses temperature 0.3.
What is Mixtral 8x22B's knowledge cutoff?
January 2024, according to OpenRouter: it knows little about later events.
Mixtral 8x22B VRAM badge
For a model card or a README: the 4-bit size and the smallest GPU it fits on, linked to this page. Data as JSON: /api/models/mixtral-8x22b.json.
Estimates, not guarantees: computed from the official config.json with the same engine as the LLM VRAM Calculator. Real usage depends on your engine version and settings.
Mistral AI, France · Released April 17, 2024