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Qwen2.5 72B VRAM Requirements

Alibaba, China · Released September 16, 2024

Qwen2.5 72B has 72.7B parameters. In BF16 its weights alone take 135 GiB; quantized to 4-bit, about 43.7 GiB. Each 32K-token request adds 10.0 GiB of KV cache. Cheapest way to run it today: 4 × RTX A4000 (16 GB) at $0.288 per hour. It calls tools.

Size your own setup in the calculator →

Qwen2.5 72B at a glance

Made by
Alibaba, China
Released
September 16, 2024
Parameters
72.7B
Context window
32K tokens
License
Qwen license
Reads
Text only
Tool calling
Supported
Knowledge cutoff
June 2024

OpenRouter

Training
7.8 × 1024 FLOP · 18 trillion tokens

Epoch AI (opens in a new tab), CC BY 4.0

Runs with
vLLM, SGLang, llama.cpp (Ollama, LM Studio), MLX (Mac)
Checked against

KV cache matches the GGUF header of Qwen/Qwen2.5-72B-Instruct-GGUF (opens in a new tab) (what llama.cpp allocates), November 6, 2026

On Ollama
ollama run qwen2.5:72b · Q4_K_M, 44.2 GiB 45M pulls (opens in a new tab)

VRAM by precision and context length

Weights plus the KV cache of one request (BF16 cache), in GiB. Add 1 to 3 GiB for the inference engine itself.

Weights formatWeights only+ 8K context+ 32K context
BF16 / FP16135138145
FP8 / INT870.072.580.0
4-bit (GGUF Q4_K_M)43.746.253.7

Qwen2.5 72B GGUF files

Exact size of each quantization in Qwen/Qwen2.5-72B-Instruct-GGUF (opens in a new tab), and the smallest GPU that runs it with llama.cpp, Ollama or LM Studio and an 8K-token context.

QuantizationFile sizeSmallest GPU
Q8_072.2 GiBRTX PRO 6000 Blackwell (96 GB)
Q6_K55.7 GiBRTX PRO 6000 Blackwell (96 GB)
Q5_K_M48.1 GiBRTX PRO 6000 Blackwell (96 GB)
Q5_046.9 GiBRTX PRO 6000 Blackwell (96 GB)
Q4_K_M41.0 GiBRTX 6000 Ada (48 GB)
Q4_038.5 GiBRTX 6000 Ada (48 GB)
Q3_K_M33.0 GiBRTX 6000 Ada (48 GB)
Q2_K25.5 GiBRTX 5090 (32 GB)

Read every day from Hugging Face. Split files are added together; vision projectors are left out.

How many GPUs to run Qwen2.5 72B

Fewest GPUs that fit the weights plus one 8K-token request. Data-center GPUs use vLLM (90% of memory usable), the others llama.cpp. Several GPUs split the model with tensor or pipeline parallelism.

GPUBF16 / FP168-bit4-bit
GeForce RTX 4090 24 GB743
GeForce RTX 5090 32 GB532
RTX PRO 6000 Blackwell 96 GB211
Mac M5 Max 128 GB 96 GB usable211
Ryzen AI Max+ 395 128 GB 96 GB usable211
DGX Spark (GB10) 128 GB211
NVIDIA H100 80 GB321
NVIDIA H200 141 GB211
NVIDIA B200 (HGX) 180 GB111

8-bit: FP8 with vLLM (INT8 on GPUs without FP8), Q8_0 with llama.cpp. 4-bit: AWQ / GPTQ with vLLM, Q4_K_M with llama.cpp, both counted at the Q4_K_M size.

Cheapest way to run Qwen2.5 72B today

For each GPU: the fewest cards that fit Qwen2.5 72B with one 8K-token request, the most faithful weight format at that count, and the cheapest on-demand price (2026-11-06).

On-demand prices from AWS, Google Cloud, Azure, RunPod, Vast.ai, Oracle Cloud, OVHcloud, Scaleway, Verda, Akash and UpCloud, checked every hour. Serving many users needs more KV cache, so more memory: size it in the calculator. Some links are affiliate links: StudioTV may earn a commission, at no extra cost to you.

AWS, Google Cloud and UpCloud prices: Spare Cores (opens in a new tab), CC BY-SA 4.0 (opens in a new tab), shared under the same license.

Or use Qwen2.5 72B through an API

No GPU to rent: these providers serve Qwen2.5 72B and bill per token. Speeds are measured by Hugging Face for one request.

ProviderOutput, per 1M tokensInput, per 1MSpeedFirst token
DeepInfra$0.400$0.36026 tokens/s326 ms

Prices and speeds from Hugging Face Inference Providers (opens in a new tab), read every day (November 6, 2026). An API wins at low volume; renting GPUs wins when they stay busy: the calculator gives the break-even.

Recommended settings for Qwen2.5 72B

Sampling defaults from the official generation_config.json (opens in a new tab) of Qwen/Qwen2.5-72B-Instruct.

SettingValue
Temperature0.7
Top-p0.8
Top-k20
Repetition penalty1.05

vLLM and SGLang apply these defaults unless a request sets its own. With llama.cpp, pass them yourself: --temp 0.7 --top-p 0.8 --top-k 20 --repeat-penalty 1.05

KV cache: how memory grows with context

Architecture: 80 layers · 80 full attention (8 KV × 128). Every layer keeps keys and values for every token (grouped-query attention), so the cache grows linearly with context.

Context per requestBF16 cacheFP8 cache
8K tokens2.50 GiB1.25 GiB
32K tokens10.0 GiB5.00 GiB

Qwen2.5 72B VRAM FAQ

How much VRAM does Qwen2.5 72B need?

In BF16 the weights alone take 135 GiB (145 GB). In FP8 that is 70.0 GiB, and about 43.7 GiB with 4-bit quantization (Q4_K_M). Each request then adds KV cache: 2.50 GiB at 8K tokens and 10.0 GiB at 32K (BF16 cache).

Can Qwen2.5 72B run on a single RTX 4090 (24 GB)?

No. Even in 4-bit it needs 3 RTX 4090s. In 4-bit it fits on a single RTX PRO 6000 Blackwell (96 GB).

Can Qwen2.5 72B run on an RTX 5090 (32 GB)?

No. Even in 4-bit it needs 2 RTX 5090s.

Can Qwen2.5 72B run on a Mac?

Yes. In 4-bit (Q4_K_M with llama.cpp) it needs a Mac with 64 GB of unified memory or more, of which macOS gives the GPU about 48 GB, for one request with an 8K-token context. In 8-bit (Q8_0) it needs 96 GB or more.

Can Qwen2.5 72B run on a DGX Spark or a Ryzen AI Max+ 395 (128 GB)?

Yes. In Q8_0 (72.5 GiB with an 8K-token context) it fits on a DGX Spark (128 GB) and on a Ryzen AI Max+ 395 with 128 GB, whose GPU gets up to 96 GB, with llama.cpp and one request.

What is the cheapest way to run Qwen2.5 72B?

On 2026-11-06, the cheapest on-demand setup is 4 × RTX A4000 (16 GB) with Q4_K_M weights on Vast.ai, at $0.288 per hour (about $210.24 per month). Next: 3 × NVIDIA L4 (24 GB) with 4-bit weights on Vast.ai, at $0.312 per hour. Sized for one 8K-token request; prices are checked every hour.

How many H100 GPUs does Qwen2.5 72B need?

With one request and an 8K-token context: 3 in BF16, 2 in FP8 and 1 in 4-bit (vLLM, 90% of memory usable). Serving many users at once needs more memory for their KV caches: the calculator sizes that for you.

Does Qwen2.5 72B support tool calling?

Yes, Qwen2.5 72B supports tool (function) calling: it can ask your application to run a function and use the result.

What temperature should I use with Qwen2.5 72B?

The official defaults are temperature 0.7, top-p 0.8, top-k 20, repetition penalty 1.05.

What is Qwen2.5 72B's knowledge cutoff?

June 2024, according to OpenRouter: it knows little about later events.

Qwen2.5 72B VRAM badge

For a model card or a README: the 4-bit size and the smallest GPU it fits on, linked to this page. Data as JSON: /api/models/qwen2-5-72b.json.

Qwen2.5 72B VRAM badge

[![Qwen2.5 72B VRAM](https://studiotvai.com/badge/qwen2-5-72b.svg)](https://studiotvai.com/vram-requirements/qwen2-5-72b)

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Estimates, not guarantees: computed from the official config.json with the same engine as the LLM VRAM Calculator. Real usage depends on your engine version and settings.